The researchers also noticed that alcoholic beverages reduced the response in the amygdala to threat indicators – – angry or fearful faces. ‘This suggests that during acute alcoholic beverages intoxication, psychological cues that signal threat are not being prepared in the brain normally because the amygdala is not responding as it should be,’ Phan stated. ‘The amygdala and the prefrontal cortex have a powerful, interactive relationship. The way the amygdala and prefrontal cortex interact enables us to accurately appraise our environment and modulate our reactions to it,’ Phan stated.Discussion: In this research, we performed targeted exome sequencing and identified an insertion variant, c.102_103insA, in the CORIN gene. The occurrence of this variant allele in the normal handles from two independent cohorts is similar to that in the 1000 genome database . This allele, nevertheless, is much more prevalent in hypertensive patients , suggesting that the variant allele may donate to hypertension in the sufferers. Previously, a corin minor allele, T555I/Q568P, is associated with center and hypertension disease. The T555I/Q568P variant allele appears exclusive in African Americans, as it is absent in other ethnic groups mostly.