Matthias Begemann, Ph.D., Birgit Zirn, M SilagraCipla.net .D., Ph.D., Gijs Santen, M.D., Ph.D., Elisa Wirthgen, Ph.D., Lukas Soellner, M.Sc.D., Roland Schweizer, M.D., Wilbert van Workum, Ph.D., Gerhard Binder, M.D., and Thomas Eggermann, Ph.D.: Short Survey: Paternally Inherited IGF2 Mutation and Growth Restriction IGF-II is a peptide hormone and a member of the IGF family members. IGF-I and IGF-II regulate somatic development and cell proliferation by binding and activating the IGF-I receptor . Although both are expressed during fetal advancement, IGF-II is considered to have a main effect on embryonic development, with IGF-I getting predominant after birth.1,2 Studies of mice have supported a major part for the IGF receptor pathway in growth: knockout of Igf1, Igf2, or Igf1r results in development retardation, whereas overexpression of Igf2 total results in overgrowth.).5,8-12 In mice, disruption of the paternal Igf2 allele causes severe prenatal development retardation, and an influence on postnatal growth in addition has been observed.13,14 Disruption of the maternal allele of Igf2 has been found to have no influence on growth.
This extensive analysis was never submitted to examine by independent scientists, making government-appointed regulators the sole arbiters of whether industry studies were reliable or not. The new study did suffer from one major limitation, in that it looked limited to published research regarding feeding rats the GM crop involved and monitoring them for wellness effects. Nevertheless, although other forms of safety research are feasible, this is the standard model for food basic safety testing. In addition, it is known that GM crop companies regularly conduct this precise type of study on their products to be able to post that data to regulators – – raising the query of why so few of the research conducted were released and submitted to peer review by independent researchers.